Prolotherapy
 

 

References from the medical literature


General

Reeves KD, Hassanein K. Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med. 2000 Mar;6(2):68-74, 77-80 http://www.drreevesonline.com/Knee%20Arthritis%20Study.pdf For a summary, go to http://www.ncbi.nlm.nih.gov/pubmed/10710805

(This is a good basic review of the principles of prolotherapy, and presents good references from the medical literature)

-Prolotherapy for musculoskeletal pain. Donna Alderman, DO. Practical Pain Management, January/February 2007. (The article can be downloaded in PDF format minus all the interesting illustrations, if you Google this title.)

- Prolo your pain away! Ross A. Hauser, M.D., Marion A. Hauser, M.S., Beulah Land Press 2004 (A book on the subject, easy to read and understand, many religious statements.)

Prolotherapy information

1) Liu Y2K et all. An in situ study of the influence of a sclerosing solution in rabbit medial collateral ligaments and its junction strength. Connective tissue research 1983; 11:95-102

2) Reeves, KD,Hassanein K, randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity Altern Ther Health Med 2000; 6:68 – 80

3) Kristina T. Jensen, PhD*,, David P. Rabago, MD,, Thomas M. Best, MD, PhD, FACSM||, Jeffrey J. Patterson, DO and Ray Vanderby, Jr, PhD Response of Knee Ligaments to Prolotherapy in a Rat Injury Model The American Journal of Sports Medicine 36:1347-1357 (2008)

4) Centeno et al • Prolotherapy for Cervical Instability 67 Pain Physician Vol. 8, No. 1, 2005 Pain Physician. 2005;8:67-72, ISSN 1533-3159

5) Klein RG et al. A randomized double-blind trial of dextrose glycerin phenol injections for chronic low back pain J spinal disord 1993; 6:23 – 33

6) Ongley MJ et al. a new approach to the treatment of chronic low back pain. Lancet 1987; 2:143 –

7) Yelland M et al. prolotherapy injections, saline injections, and exercises for chronic low back pain a randomized trial

8) Donna Alderman, DO prolotherapy for low back pain, reasonable and conservative approach to musculoskeletal low back pain,disc disease, and sciatica. Practical pain management, May 2007

9) Scarpone, Michael DO; Rabago, David P MD; Zgierska, Aleksandra MD; Arbogast, Gennie ATC; Snell, Edward MD The Efficacy of Prolotherapy for Lateral Epicondylosis: A Pilot Study Clinical Journal of Sport Medicine:Volume 18(3)May 2008pp 248-254

10) K. Dean Reeves, Khatab Hassanein. Randomized, Prospective, Placebo-Controlled Double-Blind Study of Dextrose Prolotherapy for Osteoarthritic Thumb and Finger (DIP, PIP, and Trapeziometacarpal) Joints: Evidence of Clinical Efficacy The Journal of Alternative and Complementary Medicine. August 2000, 6(4): 311-320. doi:10.1089/10755530050120673

Bradley D. Fullerton, MD High-Resolution Ultrasound and Magnetic Resonance Imaging to Document Tissue Repair After Prolotherapy: A Report of 3 Cases Arch Phys Med Rehabil Vol 89, February 2008377-385

K. Dean Reeves, MD; Bradley D. Fullerton, MD, FAAPMR and Gaston Topol, MD Evidence-Based Regenerative Injection Therapy (Prolotherapy)in Sports Medicine sports Medicine Resource Manual 2008 Chapter 50.

These last two articles show ultrasounds taken at various periods after prolotherapy treatments. These demonstrate the healing of tendons, ligaments, and menisci over a period of several months following prolotherapy treatments.

Original Research

Prolotherapy of the shoulder

Lewis JS Rotator cuff tendinopathy / subacromial impingement syndrome: Is it time for a new method of assessment? Br J Sports Med Oct 2008 (Shows how long the disability from rotator cuff injuries and tears will last, mostly because people don't understand the underlying pathology)

Rathbun JB, Macnab I: The microvascular pattern of the rotator cuff. J Bone Joint Surg Br 1970;52:540-553. (Shows how poor the circulation is to the supraspinatus tendon)

Google: American Academy of orthopedic surgeons: Rotator Cuff Tears: Frequently Asked Questions (A good overview of how effective the currently available treatments are, and what are their possible risks and side effects)What is the rotator cuff and what does it do?

What causes a rotator cuff tear and how would I know if I have one?

If I have a painful rotator cuff and keep using it, will this cause further damage?

When should I see a doctor for a rotator cuff tear?

Can a rotator cuff tear be healed or strengthened without surgery?

At what point does a rotator cuff tear require surgery to fix it?

What options are available for surgical repair?

How important is rehabilitation in the treatment of a rotator cuff tear?

Rotator cuff defect healing: A biomechanical and histologic analysis in an animal model*1
Journal of Shoulder and Elbow Surgery, Volume 7, Issue 6, Pages 599-605
J.Carpenter, S.Thomopoulos, C.Flanagan, C.DeBano, L.Soslowsky (shows that left on their own tendons healed very poorly)